Collective Cell Migration

Project Description

Collective cell migration (CCM) can be described as a large scale coordinated movement of cells that are in close proximity with each other. It is a phenomenon that is observed not only in physiological processes such as that found in embryogenesis and wound healing, but also in pathophysiological processes such as cancer metastasis. Some of the factors influencing this concerted process include cell–cell adhesion, cell–substrate interaction and mechanical cues such as geometrical constraints among others. Here, we study CCM arising from geometrical constraints, formation of suspended epithelial bridges and mechanisms involved in wound closure.

Selected Publications

1. Material approaches to active tissue mechanics

Xi, W, et al., Nature Reviews Materials, 4, 23–44, 2019.Abstract

2. Biological tissues as active nematic liquid crystals

Saw, T B, et al., Advanced Materials, 1802579, 2018.Abstract

3. Topological defects in epithelia govern cell death and extrusion

Saw, T B, et al., Nature, 544, 212-216, 2017.Abstract

4. Emergent patterns of collective cell migration under tubular confinement

Xi, W, et al., Nature Communications, 8, 1517, 2017.Article

5. Mechanobiology of collective cell migration

Saw, T B, et al., Cellular & Molecular Bioengineering, 8, 1, 3-13, 2015.Abstract

6. Mechanics of epithelial closure over non-adherent environments

Vedula, S R K, et al., Nature Communications, 6, 6111, 2015.Article

7. Epithelial bridges maintain tissue integrity during collective cell migration

Vedula, S R K, et al., Nature Materials, 13, 87–96, 2014.Abstract

8. Guidance of collective cell migration by substrate geometry

Doxzen, K, et al., Integrative Biology, 5, 8, 1026-1035, 2013.Abstract

9. Emerging modes of collective cell migration induced by geometrical constraints

Vedula, S R K, et al., PNAS, 109, 32 12974-12979, 2012.Article