Project Description

Healthy red blood cells (RBCs) are highly deformable and they can transport oxygen to various parts of the body by squeezing their way through narrow capillaries. However, they are also susceptible to malarial parasite infection. From a mechanistic perspective, the infected RBCs become stiffer and more cytoadherent. These not only result in serious impairment of blood flow, but can also lead to severe anemia, coma or even death. Thus, investigating how an infected RBC undergoes extensive molecular and structural changes and how this eventually contributes towards increased cell stiffness and cytoadherence will be important in better understanding the pathophysiology of malaria and in developing better therapeutic strategies in combating the disease.

Selected Publications

1. Graphene oxide inhibits malaria parasite invasion and delays parasitic growth in vitro

Kenry, et al., Nanoscale, 9, 14065-14073, 2017.Article

2. Single molecule and multiple bond characterization of catch bond associated cytoadhesion in malaria

Lim, Y B, et al., Scientific Reports, 7, 4208, 2017.Article

3. Expression dynamics and physiologically relevant functional study of STEVOR in asexual stages of Plasmodium falciparum infection

Singh, H, et al., Cellular Microbiology, 19, 6, e12715, 2017.Article

4. Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum

Wang, J, et al., Nature Communications, 6, 10111, 2015.Article

5. Plasmodium vivax: restricted tropism and rapid remodeling of CD71-positive reticulocytes

Malleret, B, et al., Blood, 125, 1314-1324, 2015.Article

6. Life cycle-dependent cytoskeletal modifications in plasmodium falciparum infected erythrocytes

Shi, H, et al., PLoS One, 4, e61170, 2013.Article

7. Stretching and relaxation of malaria-infected red blood cells

Ye, T, et al., Biophysical Journal, 105, 5, 1103-1109, 2013.Article

8. Host cell deformability is linked to transmission in the human malaria parasite Plasmodium falciparum

Aingaran, M, et al., Cellular Microbiology, 14, 7, 983-993, 2012.Article

9. Molecular mechanistic insights into the endothelial receptor mediated cytoadherence of Plasmodium falciparum-infected erythrocytes

Li, A, et al., Plos One, 6, 3, e16929, 2011.Article

10. Effect of plasmodial RESA protein on deformability of human red blood cells harboring Plasmodium falciparum

Mills, J P, et al., PNAS, 104, 22, 9213-9217, 2007.Article

About the MechanoBioEngineering Laboratory

We seek to address important scientific and biomedical problems using interdisciplinary approaches, develop innovative solutions and translate them for biological and healthcare applications. Our focused areas include mechanobiology of human diseases and development of mechanobiologically inspired platforms in microfluidics and wearable microdevices to better detect, diagnose and treat diseases. We have won numerous research awards and honors and have also spun out several startup companies to translate technologies from our lab to bedside and market. We are affiliated with the iHealthtech, Mechanobiology Institute, Centre for Advanced 2D Materials and SMART.

Contact Us
MechBioEng Lab

T-Lab, #08-03, 5A Engineering Drive 1
Dept of Biomedical Engineering
NUS, Singapore 117411
Tel: (65) 6516 6564
Fax: (65) 6773 2205