Cell Adhesion

Project Description

Cell-cell and cell-substrate adhesion can influence several biologically important processes such as tissue homeostasis, wound healing and even cancer metastasis. With the advancement of nano and microtechnological tools, we can now quantitatively probe cell-cell adhesion forces not only at the cellular but also molecular level. Here, we investigate the structure and function of cell adhesion proteins, quantify the adhesion forces between these proteins and examine their association with certain diseases.

Selected Publications

1. Adaptive rheology and ordering of cell cytoskeleton govern matrix rigidity sensing

Gupta, M, et al., Nature Communications, 6, 7525, 2015.Article

2. Force-dependent conformational switch of α-catenin controls vinculin binding

Yao, M, et al., Nature Communications, 5, 4525, 2014.Article

3. Actin flow and talin dynamics govern rigidity sensing in the actin-integrin linkage through talin extension

Hirata, H, et al., Journal of The Royal Society – Interface, 11, 99, 20140734, 2014.Article

4. Force-dependent vinculin binding to talin in live cells: A crucial step in anchoring the actin cytoskeleton to focal adhesions

Hirata, H, et al., American Journal of Physiology, 306, C607-C620, 2014.Article

5. Quantifying forces mediated by integral tight junction proteins in cell-cell adhesion

Vedula, S R K, et al., Experimental Mechanics, 49, 1, 3-9, 2009.Abstract

About the MechanoBioEngineering Laboratory

We seek to address important scientific and biomedical problems using interdisciplinary approaches, develop innovative solutions and translate them for biological and healthcare applications. Our focused areas include mechanobiology of human diseases and development of mechanobiologically inspired platforms in microfluidics and wearable microdevices to better detect, diagnose and treat diseases. We have won numerous research awards and honors and have also spun out several startup companies to translate technologies from our lab to bedside and market. We are affiliated with the iHealthtech, Mechanobiology Institute, Centre for Advanced 2D Materials and SMART.

Contact Us
MechBioEng Lab

T-Lab, #08-03, 5A Engineering Drive 1
Dept of Biomedical Engineering
NUS, Singapore 117411
Tel: (65) 6516 6564
Fax: (65) 6773 2205