Cancer


Project Description

Cancer is one of the leading causes of death worldwide and is a disease that results from a rapid, unrestricted and uncontrolled proliferation of abnormal cells. It is also known to cause changes in the physical properties of cells. Typically, such physical property changes can result in several fold decreases in cell stiffness as well as cell-cell adhesion. These changes are significant and can lead to cancer metastasis, severe pathology and eventual catastrophic breakdown of the bodily functions. Using micro- and nanomechanical tools, we investigate the biomechanical changes occurring in cancer cells such as circulating tumor cells to obtain better understanding their contributions to metastasis. .

Selected Publications

1. Addressing cellular heterogeneity in tumor and circulation for refined prognostication

Lim, S B, et al., PNAS, 2019. [in press]

2. Compendiums of cancer transcriptomes for machine learning applications

Lim, S B, et al., Scientific Data, 2019. [in press]

3. Pan-cancer analysis connects tumor matrisome to immune response

Lim, S B, et al., npj Precision Oncology, 3, 15, 2019.Article

4. A merged lung cancer transcriptome dataset for clinical predictive modeling

Lim, S B, et al., Scientific Data, 5, 180136, 2018.Article

5. Mechanobiology of tumor growth

Chaudhuri, P K, et al., Chemical Reviews, 118, 14, 6499-6515, 2018.Abstract

6. An extracellular matrix-related prognostic and predictive indicator for early-stage non-small cell lung cancer

Lim, S B, et al., Nature Communications, 1734, 2017.Abstract

7. Biophysical properties of human breast cancer cells measured using silicon MEMS resonators and atomic force microscopy

Corbin, E A, et al., Lab on a Chip, 15, 839-847, 2015.Abstract

8. Mechanistic adaptability of cancer cells strongly affects anti-migratory drug efficacy

Sun, W, et al., Journal of The Royal Society – Interface, 11, 99, 20140638, 2014.Article

9. Circulating tumor cells: Cancer's deadly couriers

Lim, C T, S B Hoon, Physics Today, 67, 2, 26-30, 2014.Abstract

10. Tumor dissemination: An EMT affair

Thiery, J P, C T Lim, Cancer Cell, 23, 3, 272-273, 2013.Article

11. Deformability study of breast cancer cells using microfluidics

Hou, H W, et al., Biomedical Microdevices, 11, 3, 557-564, 2009.Abstract

About the MechanoBioEngineering Laboratory

We seek to address important scientific and biomedical problems using interdisciplinary approaches, develop innovative solutions and translate them for biological and healthcare applications. Our focused areas include mechanobiology of human diseases and development of mechanobiologically inspired platforms in microfluidics and wearable microdevices to better detect, diagnose and treat diseases. We have won numerous research awards and honors and have also spun out several startup companies to translate technologies from our lab to bedside and market. We are affiliated with the iHealthtech, Mechanobiology Institute, Centre for Advanced 2D Materials and SMART.


Contact Us
MechBioEng Lab

T-Lab, #08-03, 5A Engineering Drive 1
Dept of Biomedical Engineering
NUS, Singapore 117411
Tel: (65) 6516 6564
Fax: (65) 6773 2205