Invited/Review articles

64. Future of Health Diagnostics
Lim, C T, View, 1, 1, e3, 2020. Article

63. Microfluidic tools for probing micro‐culprits
Lim, S B, , N V Menon, C T Lim, EMBO Reports, 2, 21, 2020. Abstract

62. Single-cell analysis of circulating tumor cells: Why heterogeneity matters
Lim, S B, C T Lim, W T Lim, Cancers, 2019. Article

61. Microfluidics for personalized drug screening of cancer
Menon, N V, S B Lim, C T Lim, Current Opinion in Pharmacology, 2019. Abstract

60. Liquid biopsy: one cell at a time
Lim, S B, W D Lee, J Vasudevan, W T Lim, C T Lim, npj Precision Oncology, 2019. Article

59. Flexible hybrid sensors for health monitoring: Materials and mechanisms to render wearability
Gao, Y, L T Yu, J C Yeo*, C T Lim*, Advanced Materials, 2019. Abstract

58. Advances in technologies for purification and enrichment of extracellular vesicles
Zhang, P, J C Yeo, C T Lim, SLAS Technology: Translating Life Sciences Innovation, 2019. Abstract

57. Microfluidic modelling of the tumor microenvironment for anti-cancer drug development
Shang, M L, R H Soon, C T Lim*, B L Khoo*, J Y Han*, Lab on Chip, 19, 369-386, 2019. Abstract

56. Cancer diagnosis: From tumor to liquid biopsy and beyond
V, Ramanathan, R H Soon, P Zhang, K Jiang, C T Lim, Lab on Chip, 19, 11-34, 2019. Abstract

55. Material approaches to active tissue mechanics
Xi, W*, T B Saw, D Delacour, C T Lim*, B Ladoux*, Nature Reviews Materials, 4, 23-44, 2019. Abstract

54. Potential of circulating biomarkers in liquid biopsy diagnostics
Yeo, J C, C T Lim, BioTechniques, 65, 4, 187-189, 2018. Abstract

53. Mechanobiology of tumor growth
Chaudhuri, P K, B C Low, C T Lim, Chemical Reviews, 118, 14, 6499-6515, 2018. Abstract Access the recommendation on F1000Prime

52. When stem cells meet graphene: Opportunities and challenges in regenerative medicine
Kenry, C L Wong, K P Loh, C T Lim, Biomaterials, 155, 236-250, 2018.Abstract

51. Exosomes in cancer nanomedicine and immunotherapy: Prospects and challenges
Syn, N L, L Wang, E K H Chow, C T Lim, B C Goh, Trends in Biotechnnology, 35, 7, 665-676, 2017.Abstract

50. Beyond the current state of the syntheses and applications of nanofiber technology
Kenry, C T Lim, Progress in Polymer Science, 70, 1-17, 2017.Article

49. Biocompatibility and nanotoxicity of layered two-dimensional nanomaterials
Kenry, C T Lim, ChemNanoMat, 3, 1, 5-16, 2017.Abstract

48. Emergence of the microfluidic wearable technologies
Yeo, J C, Kenry, C T Lim, Lab on a Chip, 16, 4082-4090, 2016.Abstract

47. Low-dimensional transition metal dichalcogenide nanostructures based sensors
Li, B L, J P Wang, H L Zou, S Garaj, C T Lim, J P Xie, N B Li, D T Leong, Advanced Functional Materials, 26, 39, 7034-7056, 2016.Abstract

46. Emerging flexible and wearable physical sensing platforms for healthcare and biomedical applications
Kenry, J C Yeo, C T Lim, Microsystems & Nanoengineering, 2, 16043, 2016.Abstract

45. Advances in microfluidics in combating infectious diseases
Tay, A, S R Yazdi, A Pavesi, C T Lim, M E Warkiani, Biotechnology Advances, 34, 4, 404-421, 2016.Abstract

44. Single-cell profiling approaches to probing tumor heterogeneity
Khoo, B L, P K Chaudhuri, N Ramalingam, D S W Tan, C T Lim*, M E Warkiani*, International Journal of Cancer, 139, 2, 243-255, 2016.Abstract

43. Mechanobiology of cell migration in the context of dynamic two-way cell-matrix interactions
Kurniawan, N A, P K Chaudhuri, C T Lim, Journal of Biomechanics, 49, 8, 1355-1368, 2016.Abstract

42. Uncovering mechanosensing mechanisms at the single protein level using magnetic tweezers
Le, S, R Liu, C T Lim*, J Yan*, Methods, 94, 13-18, 2016.Abstract

41. Particle-based simulations of red blood cells – A review
Ye, T, N Phan-Thien, C T Lim, Journal of Biomechanics, Special Issue, 2016.Abstract

40. Microfluidics for research and applications in oncology
Parthiv, K C, E W Majid, T Y Jing, Kenry, C T Lim, Analyst, 141, 504-524, 2016.Abstract

39. Rational design of materials interface for efficient capture of circulating tumor cells
Li, Y Q, B K Chandran, C T Lim*, X D Chen*, Advanced Science, 2, 1500118, 2015.Article

38. Mechanobiology of collective cell migration
Saw, T H, S Jain, B Ladoux, C T Lim, Cellular & Molecular Bioengineering, 8, 1, 3-13, 2015.Abstract

37. Circulating tumor cells: Cancer's deadly couriers
Lim, C T, S B Hoon, Physics Today, 67, 2, 26-30, 2014.Abstract

36. Microfluidics for cancer diagnosis
Bhagat, A A S, C T Lim, Asia Pacific Biotech News, 17, 10 &11, 44-47, 2013.Abstract

35. Graphene for smart medical devices
Ang, P K, W C Lee, K P Loh, C T Lim, Asia Pacific Biotech News,17, 1, 34-38, 2013.Abstract

34. Collective Cell Migration: A mechanistic perspective
Vedula, S R K, A Ravasio, C T Lim, B Ladoux, Physiology, 28,6, 370-379, 2013.Abstract

33. Isopore micro/nano engineered membranes– A review
Majid, E W, B L Khoo, A A S Bhagat, J Y Han, C T Lim, H Q Gong, A G Fane, ACS Nano, 7, 3, 1882–1904, 2013.Abstract

32. Tumor dissemination: An EMT affair
Thiery, J P, C T Lim, Cancer Cell, 23, 3, 272-273, 2013.Article

31. Synthesis, optical properties, and chemical-biological sensing applications of one-dimensional inorganic semiconductor nanowires
Kenry, C T Lim, Progress in Materials Science, 58, 5, 705-748, 2013.Abstract

30. Fabrication of large pores in electrospun nanofibrous scaffolds for cellular infiltration: A review
Zhong, S P, Y Z Zhang, C T Lim, Tissue Engineering Part B, 18, 2, 77-87, 2012.Abstract

29. Microfluidics for applications in cell mechanics and mechanobiology
Hou, H W, W C Lee, M C Leong, S Sonam, S R K Vedula, C T Lim, Cellular and Molecular Bioengineering, 4, 4, 591-602, 2011. Abstract

28. Microfluidic devices for blood fractionation
Hou, H W, A A S Bhagat, W C Lee, S Huang, J Y Han, C T Lim, Micromachines, 2, 319-343. 2011.Article

27. Mechanopathology of red blood cell diseases – Why mechanics matters
Lim, C T, A Li, Theoretical & Applied Mechanics Letters, 1, 1, 1-6, 2011.Abstract

26. Advances in experiments and modeling in micro- and nano-biomechanics - A mini review
Long, M, M Sato, C T Lim, J H Wu, T Adachi, Y Inoue, Cellular and Molecular Bioengineering, 4, 3, 327-339, 2011.Abstract

25. Mechanical properties of 1D metal oxide nanostructures
Varghese, B, C H Sow, C T Lim, Special issue on “Nanomechanical Testing”, Nanoscience and Nanotechnology Letters, 2, 4, 268-281, 2010.Article

24. Review on the constitutive models of tumor tissues for computational analysis
Unnikrishnan, G U, V U Unnikrishnan, J N Reddy, C T Lim, Applied Mechanics Reviews, 63, 4, 040801-040807, 2010.Abstract

23. Tissue scaffolds for skin wound healing and dermal reconstruction
Zhong, S P, Y Z Zhang, C T Lim, Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology, 2, 5, 510-25, 2010.Abstract

22. Editorial - Special Issue on “Micro and nanotechnology for biological and biomedical applications”
Lim, C T, J Guck, J Y Han, H Epinosa, Medical and Biological Engineering and Computing, vol. 48, iss 10, 941-943, 2010.Abstract

21. Microfluidics for cell separation
Bhagat, A A S, H Bow, H W Hou, S J Tan, J Y Han, C T Lim, Medical & Biological Engineering & Computing, 48, 10, 999-1014, 2010.Abstract

20. Shape and biomechanical characteristics of human red blood cells in health and disease
Diez-Silva, M, M Dao, J Y Han, C T Lim, S Suresh, MRS Bulletin, 35, 337-408, 2010. (appeared on MRS Bulletin Cover).Article

19. Introduction – Mechanobiology
Lim, C T, A Bershadsky, M P Sheetz, Journal of the Royal Society – Interface, 7, S291-S293, 2010. (appeared on journal cover).Article

18. Computational model of cell positioning: directed and collective migration in the intestinal crypt epithelium
Wong, S Y, K H Chiam, C T Lim, P Matsudaira, Journal of the Royal Society – Interface, 7, Suppl 3, S351-S363, 2010.Abstract

17. Human cell as a structure and machine – An engineering perspective
Vedula, S R K, E Mendoz, W Sun, T S Lim, A Li, Q S Li, C T Lim, IES Journal Part A: Civil and Structural Engineering, 2, 2, 153 – 160, 2009.Abstract

16. Atomistic simulations of inorganic nanowires
Dai, L, V B C Tan, C H Sow, C T Lim, Journal of Nanoscience & Nanotechnology, 9, 1-18, 2009.Abstract

15. Mechanistic insights into physiological functions of cell adhesion proteins using single molecule force spectroscopy
Vedula, S R K, T S Lim, W Hunziker, C T Lim, Molecular & Cellular Biomechanics, 5, 3, 169-82, 2008.Abstract

14. The development of biocomposite nanofibers for tissue scaffolding applications
Zhang, Y Z, C T Lim, JOM, 60, 6, 45-48, 2008.Abstract

13. Biomimetic and bioactive nanofibrous scaffolds from electrospun composite nanofibers : A review
Zhang, Y Z, B Su, J Venugopal, S Ramakrishna, C T Lim , International Journal of Nanomedicine, 2, 4, 623-638, 2008.Abstract

12. Nanotechnology and human diseases
Lee, G Y H, C T Lim, COSMOS, 3, 1, 89-101, 2007.Article

11. Biomechanics approaches to studying human diseases
Lee, G Y H, C T Lim, Trends in Biotechnology, 25, 3, 111-118, 2007.Abstract

10. Single cell mechanics study of the human disease malaria
Lim, C T, Journal of Biomechanical Science & Engineering, 1, 1, 82-92, 2006.Article

9. Experimental techniques for single cell and single molecule biomechanics
Lim, C T, E H Zhou, A Li, S R K Vedula, H X Fu, Materials Science & Engineering C: Biomimetic & Supramolecular Systems, 26, 8, 1278-1288, 2006.Abstract

8. Nanoindentation of teeth - A review
Hairul Nizam, B R, C T Lim, Journal of Experimental Mechanics, 21, 1, 35-50, 2006.Abstract

7. Mechanical characterization of nanofibers – A review
Tan EPS and Lim CT, Composites Science & Technology, 66, 9, 1102-1111, 2006.Abstract

6. Mechanical models for living cells - A review
Lim, C T, E H Zhou, S T Quek, Journal of Biomechanics, 39, 195-216, 2006.Abstract

5. Biophysical approaches for studying the integrity and function of tight junctions
Vedula, S R K, T S Lim, P J Kausalya, W Hunziker, G Rajagopal, C T Lim, Molecular & Cellular Biomechanics, 2, 3, 105-124, 2005.Abstract

4. Recent development of polymer nanofibers for biomedical and biotechnological applications
Zhang, Y Z, C T Lim, S Ramakrishna, Z M Huang, Journal of Materials Science - Materials in Medicine, 16,10,933-946, 2005.Abstract

3. Connections between single-cell biomechanics and human disease states: gastrointestinal cancer and malaria
Suresh, S, J Spatz, J P Mills, A Micoulet, M Dao, C T Lim, M Beil, T Sefferlein, Acta Biomaterialia, 1, 1, 15-30, 2005.Abstract

2. Application of biotechnology, nanotechnology and tissue engineering in cosmetic medicine
Chong, E J, C T Lim, I J Lim, T T Phan, Kosmetische Medizin, 5/6, 212-216, 2005.Abstract

1. Single cell mechanics & its connection to human diseases
Lim, C T, Asia Pacific Biotech, Special Issue - Bioengineering in Asia-Pacific, vol. 9, No. 14, July 2005.Abstract

About the MechanoBioEngineering Laboratory

We seek to address important scientific and biomedical problems using interdisciplinary approaches, develop innovative solutions and translate them for biological and healthcare applications. Our focused areas include mechanobiology of human diseases and development of mechanobiologically inspired platforms in microfluidics and wearable microdevices to better detect, diagnose and treat diseases. We have won numerous research awards and honors and have also spun out several startup companies to translate technologies from our lab to bedside and market. We are affiliated with the iHealthtech, Mechanobiology Institute, Centre for Advanced 2D Materials and SMART.

Contact Us
MechBioEng Lab

T-Lab, #08-03, 5A Engineering Drive 1
Dept of Biomedical Engineering
NUS, Singapore 117411
Tel: (65) 6516 6564
Fax: (65) 6773 2205